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RenNano

RenNano:fully human nanobody platform


RenNano mice contain full human antibody heavy chain variable regions and a modified constant region for the development of heavy-chain-only antibodies (HCAbs) or nanobodies.


  • RenNano mice have full human heavy chain variable regions and modified constant region.

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  • Obtain fully human HCAbs directly from RenNano mouse.

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  • Robust immune response compared with RenMab mouse


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  • Diverse antigen-specific antibodies discovered from RenNano


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  • High binding affinity at nanomolar range


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  • Good developability


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Nano 100 Project

The “Nano 100 Project” aims to develop fully human nanobody drugs using RenNano mice for more than 100 targets, including tumor associated antigens (TAAs), GPCRs, immune-checkpoints, cytokines, and factors related to neurological diseases.


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Posters

AACR 2023: RenNano® Mice: A Heavy-Chain-Only Antibody Platform for the Generation of Nanobody Therapeutics

AACR 2023: Discovery of RenNano®-Derived Human Heavy-Chain-Only Antibodies That Cross the Blood-Brain-Barrier