top
Please input keywords
Biocytogen
Innovative technologies drive the R&D of new drugs
Biocytogen(02315.HK) is undertaking a large-scale project to develop first-in-class and/or best-in-class antibody drugs for more than 1000 targets, known as Project Integrum (RenMice HiTS Platform).We aspire to accelerate innovation through external partnerships.
Pipeline
To streamline the entire drug development process
We are committed to working with global partners to develop innovative antibody drugs to benefit patients as soon as possible.
Antibody Discovery Platforms
Proprietary RenMice® platforms
Using its RenMice (RenMab, RenLite and RenNano) series, Biocytogen has established six fully human antibody technology platforms to meet the needs of developing drugs against different targets with different modalities.
Collaborations
Leveraging strengths offering flexibilities pursuing win-win
50therapeutic antibody co-development/out-licensing/transfer agreements kr
42target-nominated RenMiceTM licensing projects
Biocytogen and Gilead Enter Into a Multi-Target Antibody Collaboration Agreement
Beijing, China, February 19, 2024 – Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (“Biocytogen”, HKEX: 02315) today announces an antibody evaluation and option agreement with Gilead Sciences, Inc. The agreement provides Gilead access to Biocytogen’s extensive fully human antibody library generated against a wide range of therapeutic targets. Over a three-year nomination period, Gilead will nominate targets of interest and evaluate the corresponding antibodies, with the option to acquire selected antibodies for worldwide therapeutic development. Under the terms of the agreement, Biocytogen will receive a payment to enable Gilead’s evaluation of certain antibodies directed to a given nominated target. Biocytogen is eligible to receive option exercise fees along with development, regulatory and sales milestone payments for each selected antibody against the nominated targets, as well as single-digit royalties on net sales.Dr. Yuelei Shen, President and CEO of Biocytogen, said, “We are thrilled to collaborate with Gilead, a partner renowned for their drug development and commercialization expertise. Our extensive library of RenMice®-derived, fully human antibodies could serve as an important resource for Gilead to accelerate development of multiple novel antibody-based therapeutics to treat a variety of diseases. We are committed to supporting Gilead as well as our other partners in their drug development endeavors to benefit patients.”About Biocytogen’s Fully Human Antibody Library Biocytogen’s antibody library was generated using a series of proprietary RenMice® platforms, which were genetically engineered to accelerate the development of novel antibody-based therapeutics. RenMabTM mice carry the entire human antibody variable region repertoire, and can generate fully human antibodies with high diversity, low immunogenicity, outstanding specificity and affinity, and exhibit excellent developability properties. Second-generation RenLite® and RenNano® models, which generate common light chain antibodies and heavy-chain-only antibodies, respectively, further facilitate generation of fully human multi-specific antibodies or nanobodies. RenMice have also been engineered to lack specific drug targets; these targeted knockout platforms can generate antibodies with enhanced sequence and epitope diversity. This platform increases the likelihood of discovering novel species cross-reactive antibodies to facilitate downstream in vivo screening and identification of differentiated antibody candidates. A library featuring available antibody sequences along with characterization data is ready for immediate evaluation and partnership opportunities.About Biocytogen Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Founded on gene editing technology, Biocytogen leverages genetically engineered proprietary RenMice® (RenMabTM/RenLite®/RenNano®/RenTCR-mimicTM) platforms for fully human monoclonal/bispecific/multispecific antibody discovery, bispecific antibody-drug conjugate discovery, nanobody discovery and TCR-mimic antibody discovery, and has established an off-the-shelf library of >400,000 fully human antibody sequences against approximately 1000 targets for worldwide collaboration. As of June 30, 2023, 50 therapeutic antibody and multiple clinical asset co-development/out-licensing/transfer agreements and 42 target-nominated RenMice® licensing projects have been established around the globe, including several partnerships with multinational pharmaceutical companies (MNCs). Biocytogen pioneered the generation of drug target knock-in humanized models for preclinical research, and currently provides a few thousand off-the-shelf animal and cell models under the company’s sub-brand, BioMiceTM, along with preclinical pharmacology and gene-editing services for clients worldwide. Headquartered in Beijing, Biocytogen has branches in China (Haimen Jiangsu, Shanghai), USA (Boston, San Francisco), and Germany (Heidelberg). For more information, please visit http://en.biocytogen.com.cn.Biocytogen Contacts Antibody assets and platforms: BD-Licensing@biocytogen.com Media: pr@bbctg.com.cn
Biocytogen Enters into Bispecific Antibody Drug Conjugate Agreement with Radiance Biopharma
BEIJING, China & BOSTON, Massachusetts, USA—(Business Wire)----Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (“Biocytogen”, HKEX: 02315),  a global biotech company focusing on the discovery of novel antibody therapeutics, today announces that it has entered into an Exclusive Option and License Agreement with Radiance Biopharma Inc. (“Radiance”), a biotechnology company specializing in developing next generation Antibody Drug Conjugates. The agreement grants Radiance an option to license from Biocytogen a first-in-class fully human anti-HER2/TROP2 bispecific antibody-drug conjugate (BsADC) for therapeutic product development, manufacturing and commercialization for all human indications worldwide. HER2 and TROP2 are two tumor-associated antigens (TAAs) that have been found to be commonly expressed and co-expressed by multiple tumor types, including breast, gastric, colorectal, bladder, pancreatic, and non-small-cell lung cancer. Under the terms of the agreement, upon the option exercised, Biocytogen will be entitled to receive an option fee, licensing fee, development and commercialization milestone payments, as well as single-digit royalties on net sales. In addition, Biocytogen has the right to collect the sharing of sublicensing fee, if any, between Radiance and third party.Dr. Yuelei Shen, President and CEO of Biocytogen, said: “We are excited to collaborate with Radiance, a strong team with extensive experience in drug development, to develop a leading proprietary fully human bispecfic antibody drug conjugate. We are optimistic that the combination of our strength in BsADC discovery and the extensive experience of Radiance’s team will help expedite the commercialization of this dual-targeting BsADC.”Marc Lippman, MD, Chairman of the Board of Radiance said: “We are excited to enter into this Exclusive Option and License Agreement with Biocytogen for a novel human anti- HER2 and Trop2 Bispecific Antibody Drug Conjugate. Preclinical data from in vitro and in vivo assays of this BsADC shows promising high potency of anti-tumor activities in leading tumor indications. We are eager to work with Biocytogen to move the product to the clinic to benefit patients.”About Biocytogen Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Founded on gene editing technology, Biocytogen leverages genetically engineered proprietary RenMice® (RenMabTM/RenLite®/RenNano®/RenTCR-mimicTM) platforms for fully human monoclonal/bispecific/multispecific antibody discovery, bispecific antibody-drug conjugate discovery, nanobody discovery and TCR-mimic antibody discovery, and has established an off-the-shelf library of over 400,000 fully human antibody sequences against approximately 1000 targets for worldwide collaboration. As of June 30, 2023, 50 therapeutic antibody and multiple clinical asset co-development/out-licensing/transfer agreements and 42 target-nominated RenMice® licensing projects have been established around the globe, including several partnerships with multinational pharmaceutical companies (MNCs). Biocytogen pioneered the generation of drug target knock-in humanized models for preclinical research, and currently provides a few thousand off-the-shelf animal and cell models under the company’s sub-brand, BioMiceTM, along with preclinical pharmacology and gene-editing services for clients worldwide. Headquartered in Beijing, Biocytogen has branches in China (Haimen Jiangsu, Shanghai), USA (Boston, San Francisco), and Germany (Heidelberg). For more information, please visit http://en.biocytogen.com.cn.About Radiance Biopharma Radiance is focused on developing a pipeline of antibody-based cancer therapeutics including mono and bispecific Antibody Drug Conjugates (ADCs) for the treatment of cancer and to address other unmet medical needs. Marc Lippman, MD, a co-founder and Chairman of the Board of Radiance is a renowned oncologist and former founding board member of Seagen, a leader in the field of ADCs, recently acquired by Pfizer. Based in Boston, Massachusetts, Radiance has a world class, proven leadership team that brings together the best of ADC engineering, clinical, managerial expertise and track record. Radiance is an affiliated company to Alphageneron Pharmaceuticals Inc., a clinical-stage biotechnology company developing unique targeted cell and gene therapies for treating cancer and other unmet medical needs. For more information, please visit www.radiancebiopharma.com . This Media Release contains forward looking statements. The words “believe”, “expect”, “anticipate”, “intend” and “plan” and similar expressions identify forward looking statements. Actual results or performance may differ materially from any future results or performance expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materially include, among others, risks associated with pre-clinical and clinical development of products, uncertainties related to the outcome and conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, the lack of market acceptance of our products, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affiliated entities, changes and developments in technology which may render our products or technologies obsolete, and other factors. Radiance does not undertake any obligation to update or revise forward looking statements in this Media Release nor to confirm such statements to reflect subsequent events or circumstances after the date made or in relation to actual results, unless required by law. For Further information on Radiance Biopharma Info@radiancebiopharma.com Tel. 617.621.7143Investor Relations:Trinity Capital Advisors jerry.alain@trinitycapitaladvisers.com Biocytogen Contacts: Antibody assets and platforms: BD-Licensing@biocytogen.com Media: pr@bbctg.com.cn
Manhattan BioSolutions Enters into Evaluation and Potential Licensing Agreement with Biocytogen for Use of Innovative Antibodies in Targeted Therapies
by Mbio2018 | Published January 3, 2024https://manhattanbiosolutions.com/2024/01/03/biocytogen/https://www.issuewire.com/manhattan-biosolutions-enters-into-evaluation-and-potential-licensing-agreement-with-biocytogen-1787056150088970New York City, New York and Beijing, China, January 3, 2024 – Manhattan BioSolutions, Inc. (Manhattan Bio or MABS), an emerging biotech company developing innovative precision biologics, today announced it has entered into an evaluation and potential licensing agreement with Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (“Biocytogen”, HKEX: 02315), a global biotech company focused on the discovery of novel antibody-based therapeutics. Manhattan Bio gains access to antibodies targeting a promising new tumor antigen that is aberrantly overexpressed in across multiple solid tumor types.The antigen is an ovarian-specific developmental signaling protein. While normally restricted to ovary, testis and adrenal tissues, it becomes highly expressed in ovarian, endometrial and cervical cancers as well as several non-gynecological malignancies including renal, hepatic, colorectal and lung tumors. Notably, the antigen exhibits frequent overexpression particularly across treatment-resistant, aggressive and metastatic cancers. This tumor-specific expression profile makes it an exciting prospect for a precision oncology approach.The agreement provides MABS access to a diverse panel of lead fully-human monoclonal antibody assets generated via Biocytogen’s industry-leading RenMabTM and RenLite® transgenic mouse platforms. Leveraging the platforms’ fully-human antibody repertoires and high immune diversity, Biocytogen has succeeded in developing potential best-in-class antibody candidates recognizing this novel disease protein.Manhattan Bio will evaluate the antibodies in cellular and biochemical assays studies to assess binding affinity, internalization, species cross-reactivity, and other developability parameters to determine suitability for incorporation into antibody-based therapeutic modalities carrying MABS’ proprietary RNA targeting payloads. The most promising candidates may be selected by MABS’ for further development into precision medicines for the treatment of chemoresistant, aggressive or metastatic tumors.“We are extremely pleased to begin this high-potential collaboration on what we believe are groundbreaking antibodies against an emerging cancer target,” said Dr. Boris Shor, CEO of Manhattan Bio. “Combining these unique assets with our next-generation payload technologies offers an exciting opportunity to make a difference for patients battling lethal tumors with limited treatment options available.”“We are excited to provide MABS with our fully human antibodies for the development of novel ADC therapeutics,” said Dr. Yuelei Shen, President and CEO of Biocytogen. “Our well-characterized antibodies, demonstrating favorable internalization activity, hold great promise in facilitating the delivery of MABS’ novel RNA nuclease payloads for tumor treatment. This collaboration may expand the applications of our therapeutic antibodies in the field of ADC and make previous small molecule-undruggable targets druggable.”Additional financial details were not disclosed.About Manhattan BioSolutionsManhattan BioSolutions, Inc is a privately held biotechnology company focused on the development of biologic immunotherapies targeting host defense pathways for the treatment of advanced cancers. The company advances two technology platforms for drug discovery: RNA-degrader proteins, and antibody-drug conjugates (ADCs) – through collaborations with leading academic institutions. Manhattan Bio has established partnerships with the National Cancer Institute (NCI), Stony Brook University, The University at Buffalo, Binghamton University, INSERM, Nascent Biotech, EVQLV, and has been awarded grants by the National Institutes of Health (NIH), the National Science Foundation (NSF), the New Jersey Commission on Science, Innovation and Technology (CSIT), the New York State Center For Biotechnology and the University at Buffalo Center for Advanced Technology in Big Data and Health Sciences (UBCAT). Learn more at manhattanbiosolutions.com and follow Manhattan BioSolutions on LinkedIn or on X (Twitter).About BiocytogenBiocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Founded on gene editing technology, Biocytogen leverages genetically engineered proprietary RenMice® (RenMabTM/RenLite®/RenNano®/RenTCR-mimicTM) platforms for fully human monoclonal/bispecific/multispecific antibody discovery, bispecific antibody-drug conjugate discovery, nanobody discovery and TCR-mimic antibody discovery, and has established an off-the-shelf library of >400,000 fully human antibody sequences against approximately 1000 targets for worldwide collaboration. As of June 30, 2023, 50 therapeutic antibody and multiple clinical asset co-development/out-licensing/transfer agreements and 42 target-nominated RenMice® licensing projects have been established around the globe, including several partnerships with multinational pharmaceutical companies (MNCs). Biocytogen pioneered the generation of drug target knock-in humanized models for preclinical research, and currently provides a few thousand off-the-shelf animal and cell models under the company’s sub-brand, BioMiceTM, along with preclinical pharmacology and gene-editing services for clients worldwide. Headquartered in Beijing, Biocytogen has branches in China (Haimen Jiangsu, Shanghai), USA (Boston, San Francisco), and Germany (Heidelberg). For more information, please visit http://en.biocytogen.com.cn.Contact for investor inquiries:Jordana Lovett, PhDDirector of Investor Relations(857) 600-1021 ir@manhattanbiosolutions.comBiocytogen ContactsAntibody assets and platforms: BD-Licensing@biocytogen.comMedia: pr@bbctg.com.cn
Biocytogen News
Biocytogen and Gilead Enter Into a Multi-Target Antibody Collaboration Agreement
Beijing, China, February 19, 2024 – Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (“Biocytogen”, HKEX: 02315) today announces an antibody evaluation and option agreement with Gilead Sciences, Inc. The agreement provides Gilead access to Biocytogen’s extensive fully human antibody library generated against a wide range of therapeutic targets. Over a three-year nomination period, Gilead will nominate targets of interest and evaluate the corresponding antibodies, with the option to acquire selected antibodies for worldwide therapeutic development. Under the terms of the agreement, Biocytogen will receive a payment to enable Gilead’s evaluation of certain antibodies directed to a given nominated target. Biocytogen is eligible to receive option exercise fees along with development, regulatory and sales milestone payments for each selected antibody against the nominated targets, as well as single-digit royalties on net sales.Dr. Yuelei Shen, President and CEO of Biocytogen, said, “We are thrilled to collaborate with Gilead, a partner renowned for their drug development and commercialization expertise. Our extensive library of RenMice®-derived, fully human antibodies could serve as an important resource for Gilead to accelerate development of multiple novel antibody-based therapeutics to treat a variety of diseases. We are committed to supporting Gilead as well as our other partners in their drug development endeavors to benefit patients.”About Biocytogen’s Fully Human Antibody Library Biocytogen’s antibody library was generated using a series of proprietary RenMice® platforms, which were genetically engineered to accelerate the development of novel antibody-based therapeutics. RenMabTM mice carry the entire human antibody variable region repertoire, and can generate fully human antibodies with high diversity, low immunogenicity, outstanding specificity and affinity, and exhibit excellent developability properties. Second-generation RenLite® and RenNano® models, which generate common light chain antibodies and heavy-chain-only antibodies, respectively, further facilitate generation of fully human multi-specific antibodies or nanobodies. RenMice have also been engineered to lack specific drug targets; these targeted knockout platforms can generate antibodies with enhanced sequence and epitope diversity. This platform increases the likelihood of discovering novel species cross-reactive antibodies to facilitate downstream in vivo screening and identification of differentiated antibody candidates. A library featuring available antibody sequences along with characterization data is ready for immediate evaluation and partnership opportunities.About Biocytogen Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Founded on gene editing technology, Biocytogen leverages genetically engineered proprietary RenMice® (RenMabTM/RenLite®/RenNano®/RenTCR-mimicTM) platforms for fully human monoclonal/bispecific/multispecific antibody discovery, bispecific antibody-drug conjugate discovery, nanobody discovery and TCR-mimic antibody discovery, and has established an off-the-shelf library of >400,000 fully human antibody sequences against approximately 1000 targets for worldwide collaboration. As of June 30, 2023, 50 therapeutic antibody and multiple clinical asset co-development/out-licensing/transfer agreements and 42 target-nominated RenMice® licensing projects have been established around the globe, including several partnerships with multinational pharmaceutical companies (MNCs). Biocytogen pioneered the generation of drug target knock-in humanized models for preclinical research, and currently provides a few thousand off-the-shelf animal and cell models under the company’s sub-brand, BioMiceTM, along with preclinical pharmacology and gene-editing services for clients worldwide. Headquartered in Beijing, Biocytogen has branches in China (Haimen Jiangsu, Shanghai), USA (Boston, San Francisco), and Germany (Heidelberg). For more information, please visit http://en.biocytogen.com.cn.Biocytogen Contacts Antibody assets and platforms: BD-Licensing@biocytogen.com Media: pr@bbctg.com.cn
2024.02.05
Biocytogen Launches RenBiologics, A Sub-Brand Focused on Out-Licensing Fully Human Antibodies For Therapeutic Development
Beijing, China – January 24, 2024 – Biocytogen Pharmaceuticals (Beijing) Co., Ltd. (“Biocytogen”, HKEX: 02315) today announced the launch of a new sub-brand, RenBiologicsTM, to represent the company’s antibody discovery business division. RenBiologics business will cover out-licensing/co-development of the company’s extensive library of fully human antibodies, as well as licensing of RenMice®, the company’s fully human antibody/TCR discovery platforms. The RenBiologics logo features an antibody with human-centric design elements, highlighting Biocytogen's expertise in discovering fully human antibodies; the encircled design underscores the company’s dedication to becoming a global resource of fully human antibodies to expedite the development of novel antibody-based therapeutics.Antibody Licensing and Co-Development Business Biocytogen’s fully human antibody sequences were generated by proprietary RenMice strains, each engineered to lack a certain drug target gene. From March 2020 to the third quarter of 2023, Biocytogen’s large-scale therapeutic antibody R&D initiative, Project Integrum, completed over 900 target antibody discovery projects (with 40+ in the PCC to IND stages), and established an extensive antibody library of over 400K sequences available for evaluation and out-licensing to pharmaceutical and biotechnology companies.RenMice-derived fully human antibodies can be developed into novel therapies to treat numerous cancers, inflammatory and autoimmune diseases, infectious diseases, metabolic diseases, cardiovascular diseases, and neurological diseases. Target types not only include membrane and extracellular proteins, but also some intracellular proteins, many of which currently lack existing drug treatments. Screened monoclonal antibodies/nanobodies can also be developed as bispecific/multispecific antibodies, cell engagers, bispecific antibody-drug conjugates (bsADCs), and cell therapies. The primary advantage of these antibodies is that they lack the need for artificial humanization, which saves significant cost and accelerates the development process; additionally, for fully human antibodies that exhibit cross-species antigen recognition, preclinical efficacy and safety evaluation can be readily performed in various model species.Leading biopharmaceutical and biotechnology companies around the world have recognized Biocytogen's vast antibody library. Partnerships with Merck kGaA, Neurocrine, Ona Therapeutics, Radiance, ADC Therapeutics, Hansoh Pharma, FineImmune, Remegen and others, including several multinational pharmaceutical companies (MNCs), have been established for ADC, bsADC, TCR-mimic antibodies and other drug modalities in oncology and non-oncology therapeutic areas. Additionally, 4 out of 5 clinical-stage assets have entered clinical development agreements with Chipscreen NewWay Biosciences, TRACON, and Syncromune.RenMice® Fully Human Antibody/TCR Discovery Platform Licensing Business Biocytogen offers licensing and flexible partnering models for its RenMice fully human antibody/TCR discovery platforms. RenMice, which were designed using proprietary size-unlimited precise chromosome engineering (SUPCE) technology, includes RenMabTM, RenLite®, RenNano®, RenTCRTM, and RenTCR-mimicTM platforms to enable discovery of fully human monoclonal antibodies, bispecific antibodies, bsADCs, nanobodies, fully human T-cell receptors (TCRs), and TCR-mimic antibodies with high specificity and affinity. RenMice platform licensing agreements have been established with Merck KGaA, Janssen, Xencor, BeiGene, Innovent, Junshi Biosciences, Remegen and others.Dr. Yuelei Shen, Chairman and CEO of Biocytogen, said, “Officially establishing the RenBiologics division of our company signifies our commitment to becoming a global headstream of novel antibody-based therapeutics. We will continue to expand our library with best-in-class antibodies against novel targets, and plan to develop and launch novel RenMice platforms to enhance our biologic drug discovery capabilities. We look forward to forging new collaborations and advancing existing partnerships into clinic, to ultimately enrich the potential of our partners’ pipeline portfolios.”About Biocytogen Biocytogen (HKEX: 02315) is a global biotechnology company that drives the research and development of novel antibody-based drugs with innovative technologies. Founded on gene editing technology, Biocytogen leverages genetically engineered proprietary RenMice® (RenMabTM/RenLite®/RenNano®/RenTCR-mimicTM) platforms for fully human monoclonal/bispecific/multispecific antibody discovery, bispecific antibody-drug conjugate discovery, nanobody discovery and TCR-mimic antibody discovery, and has established a sub-brand, RenBiologics, to explore global partnerships for an off-the-shelf library of >400,000 fully human antibody sequences against approximately 1000 targets. As of June 30, 2023, 50 therapeutic antibody and multiple clinical asset co-development/out-licensing/transfer agreements and 42 target-nominated RenMice® licensing projects have been established around the globe, including several partnerships with multinational pharmaceutical companies (MNCs). Biocytogen pioneered the generation of drug target knock-in humanized models for preclinical research, and currently provides a few thousand off-the-shelf animal and cell models under the company’s sub-brand, BioMiceTM, along with preclinical pharmacology and gene-editing services for clients worldwide. Headquartered in Beijing, Biocytogen has branches in China (Haimen Jiangsu, Shanghai), USA (Boston, San Francisco), and Germany (Heidelberg). For more information, please visit http://en.biocytogen.com.cn.Biocytogen Contacts RenBiologics Antibody assets and platforms: BD-Licensing@biocytogen.com Media: pr@bbctg.com.cn
2024.01.24